Investigating how stiff arteries affect brain health and memory in older adults
Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathology
This study is looking at how stiff arteries might affect memory and thinking in older adults with Alzheimer's disease, using mice to see if a certain treatment can help improve brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-11049682 on NIH RePORTER |
What this research studies
This research explores the connection between large artery stiffness and cognitive decline, particularly in older adults with Alzheimer's disease. It aims to understand how increased stiffness in arteries can lead to cerebrovascular dysfunction, which may contribute to memory impairment and the progression of Alzheimer's. The study will utilize transgenic mouse models to examine the effects of artery stiffness and amyloid-β production, and will test a pharmacological intervention to mitigate these effects. By identifying these mechanisms, the research seeks to uncover potential therapeutic targets for improving brain health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients with cognitive impairment not related to vascular issues or those who are not elderly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive impairment and Alzheimer's disease in older adults.
How similar studies have performed: Previous studies have shown promising results linking vascular health to cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Walker, Ashley Elizabeth — University of Oregon
- Study coordinator: Walker, Ashley Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.