Investigating how stiff arteries affect brain health and memory in older adults
Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathology
This study is looking at how stiff arteries might affect memory and thinking in older adults with Alzheimer's, and it will test a treatment that could help make those arteries more flexible to see if it can slow down cognitive decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-10794960 on NIH RePORTER |
What this research studies
This research explores the relationship between large artery stiffness and cognitive decline, particularly in older adults with Alzheimer's disease. It aims to understand how increased stiffness in arteries can lead to cerebrovascular dysfunction, which may contribute to memory impairment and the progression of Alzheimer's. The study will utilize transgenic mouse models to simulate these conditions and test a pharmacological intervention to reduce artery stiffness. By examining these mechanisms, the research seeks to uncover potential pathways for preventing cognitive decline associated with aging and Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients who are younger or do not have any cognitive impairment or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating cognitive impairment in older adults.
How similar studies have performed: Other research has shown promising results in understanding the link between vascular health and cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Walker, Ashley Elizabeth — University of Oregon
- Study coordinator: Walker, Ashley Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.