Investigating how stem cells at the gastroesophageal junction lead to Barrett's esophagus and cancer
Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancer
This study is looking at how certain stem cells in the area where your esophagus meets your stomach might play a role in developing Barrett's esophagus and its potential progression to cancer, with the hope that the findings will help improve prevention and treatment options for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911198 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of stem cells located at the gastroesophageal junction in the development of Barrett's esophagus and its progression to esophageal adenocarcinoma. By utilizing advanced techniques such as single-cell RNA sequencing and innovative mouse models, the researchers aim to uncover the molecular mechanisms that drive these conditions. The study will explore how specific genetic changes, particularly involving the p53 gene, influence the behavior of these stem cells and contribute to disease progression. Patients may benefit from insights gained that could lead to improved prevention and treatment strategies for Barrett's esophagus and related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Barrett's esophagus or those at high risk for developing esophageal adenocarcinoma.
Not a fit: Patients with other types of esophageal conditions unrelated to Barrett's esophagus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for Barrett's esophagus and esophageal cancer.
How similar studies have performed: Previous research has shown promising results in understanding the cellular mechanisms of Barrett's esophagus, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Wang, Timothy Cragin — Columbia University Health Sciences
- Study coordinator: Wang, Timothy Cragin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.