Investigating how stem cells and blood vessel cells interact to improve muscle repair
Official title: Study the mechanisms of interaction between hiPSC-derived endothelial (ECs) and skeletal myogenic progenitor cells (MPCs) in vitro and in vivo
Funded at University of Houston · NIH-10797762 · Data updated 2026-11-12
This study is looking at how special cells from your blood vessels and muscle-building cells can work together to help heal muscles after injuries, and it’s for anyone interested in improving muscle recovery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $177,872 |
| NIH project number | 1R21AR082319-01A1 |
| Project ID | NIH-10797762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from skeletal muscle disorders who may benefit from advanced stem cell therapies.
✕Less likely to help
Patients with non-muscle related conditions or those who do not have skeletal muscle disorders may not receive any benefit from this research.
What this research studies
This research focuses on understanding the interactions between human induced pluripotent stem cell-derived endothelial cells and skeletal muscle progenitor cells. By studying these interactions both in laboratory settings and in living models, the research aims to uncover how these cells can work together to enhance muscle regeneration, especially after injuries. The approach involves examining the molecular mechanisms that facilitate communication between these cell types and assessing their combined effectiveness in promoting muscle repair.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with skeletal muscle disorders by enhancing the effectiveness of stem cell treatments.
How similar studies have gone: Previous research has shown promising results in using similar approaches to enhance cell therapies, indicating potential for success in this area.
Where this research is happening
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University of Houston
Houston, United States Active
Researchers
- Principal investigator: Darabi, Radbod — University of Houston
- Study coordinator: Darabi, Radbod
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.