Investigating how STAT2 and interferon influence cancer growth and treatment responses
Novel roles of STAT2 and IFN-I in tumorigenesis and responses to therapy
['FUNDING_P01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10910028
This study is looking at how a protein called STAT2 and a type of immune response called interferon might play different roles in cancer, sometimes helping to fight it and other times helping it grow, with the goal of finding better treatments for patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10910028 on ClinicalTrials.gov |
What this research studies
This research explores the roles of STAT2 and type I interferon (IFN-I) in cancer development and treatment responses. It examines how STAT2, traditionally thought to suppress tumors, may also promote cancer progression in certain contexts. The study utilizes various experimental models to uncover the molecular mechanisms behind these dual roles, focusing on how STAT2 interacts with other proteins to influence cancer cell behavior. Patients may benefit from insights gained that could lead to improved therapies targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with lung or breast cancer, particularly those with aggressive disease characteristics.
Not a fit: Patients with cancers unrelated to the pathways involving STAT2 and IFN-I may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better manage cancer by targeting the roles of STAT2 and IFN-I.
How similar studies have performed: While the roles of STAT2 in cancer are being actively explored, this specific investigation into its dual functions is relatively novel and has not been extensively tested.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STARK, GEORGE ROBERT — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: STARK, GEORGE ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.