Investigating how Staphylococcus bacteria evade the immune system
Novel Enzyme Inhibitors in the Innate Immune Evasion Repertoire of Staphylococci
This study is looking at how a common germ called Staphylococcus aureus tricks our immune system and aims to find new ways to help our bodies fight off infections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project ID | NIH-11034110 on NIH RePORTER |
What this research studies
This research focuses on understanding how Staphylococcus aureus, a common bacterium, evades the human immune system. It examines specific proteins produced by the bacteria that inhibit key enzymes involved in the immune response, particularly those related to neutrophils and the complement system. By identifying and characterizing these proteins, the research aims to uncover new targets for therapies that could enhance the immune system's ability to fight bacterial infections. The approach involves biochemical analysis and molecular recognition studies to understand the interactions between these bacterial proteins and immune enzymes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently suffering from infections caused by Staphylococcus aureus.
Not a fit: Patients with infections caused by other types of bacteria that do not involve Staphylococcus aureus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the effectiveness of the immune response against Staphylococcus infections.
How similar studies have performed: Other research has shown success in targeting bacterial evasion mechanisms, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
Manhattan, United States
- Kansas State University — Manhattan, United States (Active)
Researchers
- Principal investigator: Geisbrecht, Brian V — Kansas State University
- Study coordinator: Geisbrecht, Brian V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.