Investigating how Staphylococcus aureus and eicosanoids contribute to inflammation in aspirin-exacerbated respiratory disease.
Staphylococcus aureus and eicosanoid dysregulation as drivers of inflammation in aspirin-exacerbated respiratory disease
['FUNDING_R21'] · MAYO CLINIC ROCHESTER · NIH-11132942
This study is looking at how a common germ in nasal polyps might affect inflammation in people with aspirin-exacerbated respiratory disease (AERD), with the goal of finding better ways to diagnose and treat this condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11132942 on ClinicalTrials.gov |
What this research studies
This research focuses on aspirin-exacerbated respiratory disease (AERD), a condition where patients experience severe asthma and nasal polyps, particularly in response to aspirin and similar medications. The study aims to understand how Staphylococcus aureus, a common bacterium found in nasal polyps, influences inflammation and the production of certain inflammatory substances called eicosanoids. By examining the relationship between these factors, the researchers hope to identify new diagnostic markers and treatment strategies for AERD, which currently lacks effective laboratory tests for diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with aspirin-exacerbated respiratory disease, particularly those experiencing severe asthma and nasal polyps.
Not a fit: Patients who do not have aspirin-exacerbated respiratory disease or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients suffering from aspirin-exacerbated respiratory disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of Staphylococcus aureus in respiratory diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JERSCHOW, ELINA — MAYO CLINIC ROCHESTER
- Study coordinator: JERSCHOW, ELINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.