Investigating how Staphylococcus aureus and eicosanoids contribute to inflammation in aspirin-exacerbated respiratory disease.
Official title: Staphylococcus aureus and eicosanoid dysregulation as drivers of inflammation in aspirin-exacerbated respiratory disease
Funded at Mayo Clinic Rochester · NIH-11132942 · Data updated 2026-11-12
This study is looking at how a common germ in nasal polyps might affect inflammation in people with aspirin-exacerbated respiratory disease (AERD), with the goal of finding better ways to diagnose and treat this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $201,587 |
| NIH project number | 5R21AI171306-02 |
| Project ID | NIH-11132942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with aspirin-exacerbated respiratory disease, particularly those experiencing severe asthma and nasal polyps.
✕Less likely to help
Patients who do not have aspirin-exacerbated respiratory disease or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research focuses on aspirin-exacerbated respiratory disease (AERD), a condition where patients experience severe asthma and nasal polyps, particularly in response to aspirin and similar medications. The study aims to understand how Staphylococcus aureus, a common bacterium found in nasal polyps, influences inflammation and the production of certain inflammatory substances called eicosanoids. By examining the relationship between these factors, the researchers hope to identify new diagnostic markers and treatment strategies for AERD, which currently lacks effective laboratory tests for diagnosis.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients suffering from aspirin-exacerbated respiratory disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of Staphylococcus aureus in respiratory diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Jerschow, Elina — Mayo Clinic Rochester
- Study coordinator: Jerschow, Elina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.