Investigating how splicing of a specific gene affects heart function
Official title: Alternative splicing regulation of CLTC in the heart
Funded at Univ of North Carolina Chapel Hill · NIH-10984446 · Data updated 2026-11-12
This study is looking at how changes in a specific gene might affect heart health and development, using advanced techniques to see how these changes could help us understand heart diseases better, which could be helpful for people with heart conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $40,064 |
| NIH project number | 5F31HL170617-02 |
| Project ID | NIH-10984446 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiovascular diseases or those at risk of developing heart conditions.
✕Less likely to help
Patients with non-cardiovascular conditions or those without any heart-related issues may not benefit from this research.
What this research studies
This research focuses on understanding how alternative splicing of the CLTC gene impacts heart function and development. By examining how this splicing event occurs in cardiomyocytes, the study aims to uncover the regulatory mechanisms behind it and its implications for cardiovascular diseases. The researchers will utilize CRISPR technology to manipulate splicing patterns in animal models, allowing them to observe the effects on heart health and disease progression. This work could lead to new insights into the molecular underpinnings of heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for treating heart diseases by targeting splicing mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding alternative splicing in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Gentile, Gabrielle Marie — Univ of North Carolina Chapel Hill
- Study coordinator: Gentile, Gabrielle Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.