Investigating how specific types of brain cells in the entorhinal cortex are affected in Alzheimer's disease
Cell-type-specific vulnerability of the entorhinal cortex in Alzheimer's disease
This study is looking at certain types of brain cells in an area important for memory, to see which ones are most affected by Alzheimer's disease, with the hope of finding ways to help improve memory loss for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10766808 on NIH RePORTER |
What this research studies
This research focuses on understanding the vulnerability of specific neuron types in the entorhinal cortex, which is crucial for memory and is significantly impacted in Alzheimer's disease (AD). By using advanced techniques such as histological analyses and in vivo recordings, the study aims to identify which neurons in this brain region are most susceptible to degeneration. The researchers will also explore how the death of these specific cells contributes to memory loss in AD. This work could provide insights into the underlying mechanisms of Alzheimer's and potentially lead to targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-stage Alzheimer's disease or those at risk for developing the condition.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating memory impairment in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding neurodegeneration in Alzheimer's, but this specific focus on cell-type vulnerability is a novel approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Igarashi, Kei M — University of California-Irvine
- Study coordinator: Igarashi, Kei M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.