Investigating how specific T cell factors affect gut health and disease
Official title: A T cell STAT3/BATF-axis regulates intestinal γδ T cell homeostasis and disease
Funded at Purdue University · NIH-10851705 · Data updated 2026-11-12
This study is looking at how certain immune cells in the gut help keep things balanced and healthy, especially for people with inflammatory bowel diseases (IBD), and it hopes to find new ways to improve treatment by understanding these processes better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | August 21, 2023 |
| Project end | August 20, 2025 |
| Funding year | 2024 |
| Award (this year) | $40,468 |
| NIH project number | 5F31DK135369-02 |
| Project ID | NIH-10851705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients with non-inflammatory gastrointestinal disorders may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of certain T cell transcription factors, STAT3 and BATF, in maintaining the balance of γδ T cells in the intestines, which is crucial for gut health. By using mouse models that mimic human inflammatory bowel diseases (IBD), the researchers aim to explore how disruptions in these factors can lead to gut microbiota imbalances and increased disease severity. The study will involve advanced techniques such as cell culture and genomic profiling to identify potential new treatment strategies for IBD. Patients may benefit from insights gained into how their gut microbiota and immune responses can be better managed.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory bowel diseases more effectively.
How similar studies have gone: Previous research has shown promising results in targeting immune responses and gut microbiota in similar inflammatory conditions, suggesting potential for success in this approach.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Anderson, Nicole — Purdue University
- Study coordinator: Anderson, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.