Investigating how specific sugar changes affect the spread of pancreatic cancer
Truncated O-glycan-dependent mechanisms inducing metastatic dissemination in pancreatic cancer
This study is looking at how certain sugar changes in pancreatic cancer cells might affect how the cancer grows and spreads, and it hopes to find new treatment ideas that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10993976 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of truncated O-glycans in the progression and metastasis of pancreatic cancer. It examines how the enzyme C1GALT1, which is responsible for adding sugar molecules to proteins, is altered in pancreatic cancer cells, leading to changes in glycosylation patterns. By utilizing CRISPR technology to knock out C1GALT1 in pancreatic cancer cells, the study aims to uncover how these changes contribute to tumor growth and spread. Patients may benefit from insights that could lead to new therapeutic strategies targeting these glycan alterations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic cancer, particularly those with poorly differentiated tumors.
Not a fit: Patients with early-stage pancreatic cancer or those without significant glycan alterations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the mechanisms of metastasis in pancreatic cancer.
How similar studies have performed: While the specific approach of targeting truncated O-glycans in pancreatic cancer is relatively novel, similar studies have shown promising results in other cancer types.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Ponnusamy, Moorthy P. — University of Nebraska Medical Center
- Study coordinator: Ponnusamy, Moorthy P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.