Investigating how specific signaling pathways can help repair the heart after injury
Project 2 - Shh and Etv2 Signaling Pathways and Cardiovascular Repair in Mouse and Pig
This study is looking at how certain signals in the body can help the heart heal itself after damage, like from a heart attack, and it’s aimed at finding new ways to improve heart recovery for people with heart problems.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10897867 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind heart repair, focusing on the Shh and Etv2 signaling pathways that influence heart cell growth and blood vessel formation. By studying these pathways in both mouse and pig models, the researchers aim to understand how to enhance the heart's ability to regenerate after damage, such as from a heart attack. The approach includes using advanced genetic models and bioinformatics tools to analyze the effects of these pathways on heart cells and blood vessels. This could lead to new strategies for treating cardiovascular diseases in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases or those at risk of heart injuries.
Not a fit: Patients with non-cardiovascular conditions or those who have already experienced irreversible heart damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve heart repair and recovery after injuries.
How similar studies have performed: Previous research has shown promise in using similar signaling pathways for heart regeneration, indicating potential for success in this approach.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Garry, Daniel J. — University of Alabama at Birmingham
- Study coordinator: Garry, Daniel J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.