Investigating how specific signaling in brain cells affects glaucoma-related cell death
Official title: Compartmentalized cAMP signaling in reactive astrocytes
Funded at Stanford University · NIH-11210519 · Data updated 2026-11-12
This study is looking at how certain brain cells called reactive astrocytes behave in glaucoma, with the hope of finding new ways to protect the cells in your eyes that are important for vision, so that we can develop better treatments for people with glaucoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2024 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $41,072 |
| NIH project number | 3R01EY033816-01A1S1 |
| Project ID | NIH-11210519 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glaucoma or other optic neuropathies who are experiencing vision loss.
✕Less likely to help
Patients with conditions unrelated to glaucoma or those who have already lost significant vision may not benefit from this research.
What this research studies
This research focuses on understanding the role of reactive astrocytes in glaucoma, a leading cause of irreversible blindness. By examining how compartmentalized cAMP signaling affects these brain cells, the study aims to uncover mechanisms that could protect retinal ganglion cells from death. Using advanced techniques like single-cell RNA sequencing, researchers will analyze the cellular responses to stress and how these responses can be manipulated to improve cell survival. The goal is to identify potential therapeutic targets that could lead to better treatments for glaucoma patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent vision loss in glaucoma patients by protecting critical retinal cells.
How similar studies have gone: Previous research has shown promise in targeting astrocytes for neuroprotection in various neurological conditions, suggesting that this approach may yield beneficial results.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Goldberg, Jeffrey L — Stanford University
- Study coordinator: Goldberg, Jeffrey L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.