Investigating how specific receptors affect diabetic retinopathy
Official title: Toward Targeting GPR31 and GPR39 Signaling in Diabetic Retinopathy
Funded at Oakland University · NIH-10946912 · Data updated 2026-11-12
This study is looking at how certain receptors in the eye might affect vision problems caused by diabetes, with the hope of finding new ways to help people with diabetic retinopathy keep their sight.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $184,117 |
| NIH project number | 1R21EY036537-01 |
| Project ID | NIH-10946912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic retinopathy.
✕Less likely to help
Patients without diabetes or those who do not have any signs of diabetic retinopathy may not benefit from this research.
What this research studies
This research focuses on understanding the role of GPR31 and GPR39 receptors in diabetic retinopathy, a condition that can lead to vision loss in people with diabetes. The study aims to explore how these receptors interact with certain metabolites that are elevated in diabetes, potentially contributing to inflammation and vascular issues in the retina. By examining these mechanisms in retinal cells, the research seeks to uncover new insights that could lead to better treatments for diabetic retinopathy.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent or treat vision loss in patients with diabetic retinopathy.
How similar studies have gone: While the specific role of GPR31 and GPR39 in diabetic retinopathy has not been extensively studied, previous research has shown promising results in targeting similar pathways for other conditions.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Al-Shabrawey, Mohamed Al-Sayed — Oakland University
- Study coordinator: Al-Shabrawey, Mohamed Al-Sayed
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.