Investigating how specific proteins regulate energy production in heart cells.
A BRD4-GATA4 module cooperatively regulates mitochondrial bioenergetic homeostasis in the adult heart
This study is looking at how two proteins, BRD4 and GATA4, help heart cells produce energy, especially when someone has heart failure, with the hope of finding new treatments that could improve heart health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10884274 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of two proteins, BRD4 and GATA4, in managing energy production within heart cells, particularly in the context of heart failure. By examining how these proteins interact and influence mitochondrial function, the study aims to uncover new mechanisms that could lead to innovative treatments for heart failure. The approach involves advanced techniques like ATAC sequencing to analyze gene regulation and energy metabolism in cardiomyocytes. Patients may benefit from insights that could lead to novel therapies targeting mitochondrial dysfunction in heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure, particularly those under 21 years old.
Not a fit: Patients with heart conditions unrelated to mitochondrial dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce mortality in patients with heart failure.
How similar studies have performed: Other research has shown promising results in targeting mitochondrial function for heart disease treatment, indicating that this approach has potential.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Padmanabhan, Arun — University of California, San Francisco
- Study coordinator: Padmanabhan, Arun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.