Investigating how specific proteins regulate blood vessel development
Structural Investigation of p120RasGAP's regulation by phosphorylated binding partners
This study is looking at a protein called p120RasGAP to see how it helps form blood vessels and how it interacts with other proteins, which could help us understand conditions like Vein of Galen Malformation and Capillary Malformation-Arteriovenous Malformation Syndrome.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10888995 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called p120RasGAP in the development of blood vessels, particularly how it interacts with other proteins that are modified by phosphorylation. By examining these interactions, the research aims to uncover the mechanisms that may lead to vascular disorders such as Vein of Galen Malformation and Capillary Malformation-Arteriovenous Malformation Syndrome. The approach includes structural and biochemical studies to analyze how these binding partners influence the activity of p120RasGAP. This could provide insights into the underlying causes of these vascular conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children diagnosed with vascular malformations.
Not a fit: Patients with vascular disorders not related to the EphB4-p120RasGAP signaling pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for patients with vascular disorders.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions in vascular development, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Vish, Kimberly Jean — Yale University
- Study coordinator: Vish, Kimberly Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.