Investigating how specific proteins on cancer cells can be targeted for leukemia treatment
Official title: Alternatively spliced cell surface proteins as drivers of leukemogenesis and targets for immunotherapy
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-10890127 · Data updated 2026-11-12
This study is looking at how to use special proteins found in leukemia cells to create better treatments, like CAR T-cell therapy, that could help patients with blood cancers feel better and fight their illness more effectively.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $219,800 |
| NIH project number | 5R21CA280367-02 |
| Project ID | NIH-10890127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or other acute leukemias who may benefit from innovative immunotherapy approaches.
✕Less likely to help
Patients with chronic forms of leukemia or those who do not have specific genetic mutations related to the study may not benefit from this research.
What this research studies
This research focuses on understanding how certain proteins that are altered in leukemia cells can be targeted for immunotherapy. By studying the genetic changes that lead to these proteins, the researchers aim to develop new treatments that can effectively attack leukemia. The approach involves identifying combinations of these proteins to enhance the effectiveness of CAR T-cell therapy, which is a promising treatment for blood cancers. Patients may have the opportunity to benefit from novel therapies developed through this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies for patients with acute leukemia, improving survival rates and treatment outcomes.
How similar studies have gone: Previous research has shown promise in targeting similar proteins in other cancers, suggesting that this approach may be effective for leukemia as well.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Perna, Fabiana — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Perna, Fabiana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.