Investigating how specific proteins influence blood vessel formation
Official title: Role of SHE and ABL signaling in vascular tubulogenesis
Funded at University of South Florida · NIH-10988310 · Data updated 2026-11-12
This study is looking at how certain proteins help shape blood vessels, which is important for healthy blood flow, and it could lead to better treatments for people with blood vessel problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | March 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $550,204 |
| NIH project number | 5R01HL163161-03 |
| Project ID | NIH-10988310 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with vascular disorders, particularly those experiencing issues related to blood vessel malformations.
✕Less likely to help
Patients with vascular conditions unrelated to lumen size or those not exhibiting malformations may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms that regulate the size of blood vessel lumens, which is crucial for proper vascular development. The study examines the roles of two proteins, Abl kinase and She, in the process of tubulogenesis using advanced 3D cell culture techniques. By utilizing zebrafish models and human vascular cells, the researchers aim to uncover how these proteins interact and affect blood vessel formation, potentially leading to new insights into vascular diseases. Patients may benefit from this research as it could lead to improved treatments for conditions associated with malformed blood vessels.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic targets for treating vascular diseases linked to abnormal blood vessel formation.
How similar studies have gone: While the specific role of Abl and She in vascular lumen regulation is novel, similar studies have shown success in understanding vascular development and signaling pathways.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Sumanas, Saulius — University of South Florida
- Study coordinator: Sumanas, Saulius
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.