Investigating how specific proteins in smooth muscle cells can protect against artery plaque buildup
Atheroprotection by smooth muscle selective RhoGAPs
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10880704
This study is looking at how certain cells and proteins in your blood vessels affect heart health and the buildup of plaque, which can lead to serious heart problems, and it may involve patients in checking their genes and heart health to find ways to prevent or slow down this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10880704 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of smooth muscle cells in the development and stability of atherosclerosis, a condition that leads to serious cardiovascular diseases. The study examines how certain proteins, specifically RhoGAPs, influence blood pressure and vascular stiffness, which are critical factors in plaque formation. By analyzing genetic variations and their effects on cardiovascular outcomes, the research aims to uncover mechanisms that could prevent or reduce the progression of atherosclerosis. Patients may be involved in genetic assessments and monitoring of cardiovascular health as part of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cardiovascular disease or those diagnosed with hypertension or atherosclerosis.
Not a fit: Patients who do not have cardiovascular risk factors or existing conditions related to atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis, potentially reducing the risk of heart attacks and strokes.
How similar studies have performed: Previous research has shown promising results in understanding the role of smooth muscle cell signaling in cardiovascular health, indicating that this approach may yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAYLOR, JOAN M — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: TAYLOR, JOAN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.