Investigating how specific proteins help heal corneal wounds
Official title: The Aquaporin-3/Phospholipase D2 Signaling Pathway in Corneal Wound Healing
Funded at Charlie Norwood VA Medical Center · NIH-10664930 · Data updated 2026-11-12
This study is looking at how two proteins help heal eye injuries, and it could lead to better treatments for people with corneal wounds.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Charlie Norwood VA Medical Center NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | July 1, 2020 |
| Project end | September 30, 2025 |
| Funding year | 2023 |
| NIH project number | 5I01BX005055-04 |
| Project ID | NIH-10664930 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with corneal injuries or conditions that impair corneal healing.
✕Less likely to help
Patients with non-corneal related injuries or conditions may not benefit from this research.
What this research studies
This research focuses on understanding the interaction between two proteins, aquaporin-3 and phospholipase D2, which play a crucial role in the healing of corneal wounds. By studying these proteins in both laboratory settings and in mouse models, the researchers aim to uncover how they facilitate the transport of glycerol and promote wound healing in the cornea. The findings could lead to new insights into the mechanisms of corneal repair and potential therapeutic targets for improving healing processes in patients with corneal injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from corneal wounds, enhancing their healing and recovery.
How similar studies have gone: Previous studies have shown promising results in understanding similar signaling pathways in wound healing, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Charlie Norwood VA Medical Center
Augusta, United States Active
Researchers
- Principal investigator: Bollag, Wendy B — Charlie Norwood VA Medical Center
- Study coordinator: Bollag, Wendy B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.