Investigating how specific proteins control gene expression during cell differentiation
Understanding CTCF Boundaries Controlling Hox Gene Expression
This study is looking at how certain proteins help control which genes are turned on or off as cells develop, and it hopes to find out how this knowledge can help us understand and treat different diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10801657 on NIH RePORTER |
What this research studies
This research focuses on understanding how chromatin interactions in the genome regulate gene expression during the differentiation of mammalian cells. It examines the roles of key proteins, such as CTCF and cohesin, in forming chromatin loops that insulate repressed gene regions from those that are actively transcribing. By studying specific mutations in these proteins, particularly in the context of the Hox gene clusters, the research aims to uncover the mechanisms that dictate cell type-specific gene expression. Patients may benefit from insights gained into how gene regulation impacts various diseases and developmental processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or developmental issues related to gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or chromatin structure may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene expression dysregulation.
How similar studies have performed: Other research has shown success in understanding gene regulation through chromatin interactions, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Reinberg, Danny — University of Miami School of Medicine
- Study coordinator: Reinberg, Danny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.