Investigating how specific proteins contribute to heart rhythm disorders.
The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
This study is looking at how two specific proteins in heart cells might play a role in causing atrial fibrillation, a common heart rhythm issue, and it aims to find new ways to help people who have this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11246107 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind atrial fibrillation (AF), a common heart rhythm disorder. It examines the roles of two proteins, interleukin-1b and gasdermin-D, in heart cells and how they may contribute to the development of AF. By using both mouse models and human heart tissue, the researchers aim to uncover how these proteins interact and potentially create a cycle that exacerbates arrhythmias. The findings could lead to new insights into treatment strategies for patients suffering from AF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atrial fibrillation or those at high risk for developing this condition.
Not a fit: Patients without a history of atrial fibrillation or related cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for preventing or treating atrial fibrillation.
How similar studies have performed: Previous studies have shown promising results in understanding the role of inflammasomes in cardiac conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.