Investigating how specific proteins contribute to heart rhythm disorders.
The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
This study is looking at how two proteins in heart cells might cause or worsen atrial fibrillation, a common heart rhythm problem, and it aims to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10995297 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind atrial fibrillation, a common heart rhythm disorder. It examines the roles of two proteins, interleukin-1b and gasdermin-D, in heart cells and how they may contribute to the development of arrhythmias. By using both mouse models and human heart tissue, the researchers aim to uncover how these proteins interact and potentially create a cycle that exacerbates heart rhythm issues. The findings could lead to new insights into treatment options for patients with atrial fibrillation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atrial fibrillation or those at high risk for developing this condition.
Not a fit: Patients without a history of atrial fibrillation or related cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating atrial fibrillation.
How similar studies have performed: Previous research has shown that targeting inflammasome pathways can be effective in managing other inflammatory conditions, suggesting potential for success in this novel approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Na — Baylor College of Medicine
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.