Investigating how specific proteins can control HIV activity
Official title: Delving into a Unique Transcription Factor Family to Regulate HIV Transcription
Funded at University of Florida · NIH-11124892 · Data updated 2026-11-12
This study is looking at how certain proteins in our body can help control HIV better, with the hope of finding new ways to manage the virus without needing constant medication, making life easier for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $241,500 |
| NIH project number | 5R21AI186602-02 |
| Project ID | NIH-11124892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and may benefit from new treatment strategies.
✕Less likely to help
Patients who are not living with HIV or those who have advanced stages of the disease with limited treatment options may not benefit from this research.
What this research studies
This research focuses on understanding how a unique family of proteins, known as pioneer factors, can influence the behavior of HIV in the body. By examining how these proteins interact with the genetic material of HIV, the researchers aim to develop new strategies for achieving long-term control of the virus without the need for ongoing antiretroviral therapy. The study will involve analyzing the chromatin environment around the HIV gene to see how it can be modified to suppress viral activity. This could lead to innovative approaches for treating HIV and improving the lives of those affected.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that allow people living with HIV to maintain viral remission without continuous medication.
How similar studies have gone: Previous research has shown promise in using similar approaches to modulate HIV activity, indicating potential for success in this area.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Mediouni Jablonski, Sonia — University of Florida
- Study coordinator: Mediouni Jablonski, Sonia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.