Investigating how specific proteins can control HIV activity
Delving into a Unique Transcription Factor Family to Regulate HIV Transcription
This study is looking at how certain proteins in our body can help control HIV better, with the hope of finding new ways to manage the virus without needing constant medication, making life easier for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11124892 on NIH RePORTER |
What this research studies
This research focuses on understanding how a unique family of proteins, known as pioneer factors, can influence the behavior of HIV in the body. By examining how these proteins interact with the genetic material of HIV, the researchers aim to develop new strategies for achieving long-term control of the virus without the need for ongoing antiretroviral therapy. The study will involve analyzing the chromatin environment around the HIV gene to see how it can be modified to suppress viral activity. This could lead to innovative approaches for treating HIV and improving the lives of those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and may benefit from new treatment strategies.
Not a fit: Patients who are not living with HIV or those who have advanced stages of the disease with limited treatment options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that allow people living with HIV to maintain viral remission without continuous medication.
How similar studies have performed: Previous research has shown promise in using similar approaches to modulate HIV activity, indicating potential for success in this area.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Mediouni Jablonski, Sonia — University of Florida
- Study coordinator: Mediouni Jablonski, Sonia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.