Investigating how specific proteins affect the structure and function of microfibrils in tissues.
Role of POGLUT2 and POGLUT3 in regulating microfibril structure and function
This study is looking at how two proteins, POGLUT2 and POGLUT3, help change other proteins that are important for keeping our tissues, like lungs and blood vessels, stretchy and healthy, which could help us learn more about conditions like Marfan Syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-10876247 on NIH RePORTER |
What this research studies
This research focuses on the role of two proteins, POGLUT2 and POGLUT3, in modifying other proteins that are crucial for the structure of microfibrils, which are important for the elasticity of various tissues, including the lungs and blood vessels. By examining how these proteins add glucose to specific regions of other proteins, the research aims to understand their impact on tissue function and homeostasis. The study employs advanced techniques like glycoproteomic mass spectrometry to analyze protein modifications in human cells. This could lead to insights into conditions like Marfan Syndrome, which affects connective tissue.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with connective tissue disorders, particularly those with Marfan Syndrome or related conditions.
Not a fit: Patients with unrelated genetic or acquired conditions that do not affect connective tissue may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive strategies for conditions related to connective tissue disorders.
How similar studies have performed: While the specific approach of investigating O-glucosylation in this context is novel, related research has shown success in understanding protein modifications and their implications in connective tissue disorders.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Haltiwanger, Robert S. — University of Georgia
- Study coordinator: Haltiwanger, Robert S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.