Investigating how specific proteins affect signaling in neurological diseases.
Official title: Serine/Threonine Phosphatases in Neurological Diseases
Funded at University of Connecticut Sch of Med/dnt · NIH-11004985 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain might affect signaling and communication between nerve cells, especially in relation to Alzheimer's disease, to help find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $455,135 |
| NIH project number | 5R01NS124666-03 |
| Project ID | NIH-11004985 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline.
✕Less likely to help
Patients with neurological conditions unrelated to Alzheimer's or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding the role of serine/threonine phosphatases in neuronal signaling, particularly in relation to diseases like Alzheimer's. The team will explore how these proteins interact with other molecules in neurons and how their functions may change in response to different stimuli. By identifying the specific substrates these phosphatases target, the research aims to uncover new insights into the mechanisms behind neurological disorders. This work could lead to the development of new therapeutic strategies for conditions such as Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Alzheimer's disease and other neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding neuronal signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Peti, Wolfgang — University of Connecticut Sch of Med/dnt
- Study coordinator: Peti, Wolfgang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.