Investigating how specific proteins affect RNA processing and degradation
Official title: The Roles of Rnt1 and Putative Endoribonucleases in mRNA Processing and Degradation
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11003665 · Data updated 2026-11-12
This study is looking at how specific proteins help control the way our genes work by managing messenger RNA, which could lead to better understanding and treatments for patients with conditions like cancer and rare inherited diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 29, 2022 |
| Project end | December 28, 2025 |
| Funding year | 2025 |
| Award (this year) | $42,348 |
| NIH project number | 5F31GM149143-03 |
| Project ID | NIH-11003665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with rare inherited diseases, cancers, or neurodegenerative disorders related to RNA processing and degradation.
✕Less likely to help
Patients with conditions unrelated to RNA regulation or those not affected by genetic dysregulation may not benefit from this research.
What this research studies
This research focuses on understanding how certain proteins regulate gene expression by processing and degrading messenger RNA (mRNA). By identifying the targets and cleavage sites of these proteins, the study aims to uncover the mechanisms that maintain cellular health and prevent diseases like cancer and neurodegenerative disorders. Patients may benefit from insights gained into the genetic causes of their conditions, particularly those with rare inherited diseases linked to RNA regulation. The research employs advanced bioinformatics techniques to analyze the roles of these proteins in cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of diseases and potential therapeutic targets for treatment.
How similar studies have gone: Previous research has shown success in understanding RNA regulation and its implications for various diseases, indicating that this approach is promising.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Notice, Lee-Ann Shari — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Notice, Lee-Ann Shari
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.