Investigating how specific proteins affect myelination in the brain
Using genetic approaches to explore the role of group I PAKs in developmental myelination of the mammalian CNS
This study is looking at how certain proteins in the brain help with the growth of myelin, which is important for healthy brain development, especially in kids with neurodevelopmental disorders.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10528035 on NIH RePORTER |
What this research studies
This research explores the role of group I PAKs, a family of proteins, in the development of myelin in the central nervous system of mammals. By using genetic techniques, the study aims to understand how these proteins influence the growth and function of oligodendrocytes, the cells responsible for myelination. The research focuses on specific mutations in these proteins that have been linked to neurodevelopmental disorders in children, aiming to uncover their impact on brain development and myelination processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include children with neurodevelopmental abnormalities or myelination disorders linked to mutations in group I PAKs.
Not a fit: Patients without genetic mutations affecting group I PAKs or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treatments for neurodevelopmental disorders associated with myelination issues.
How similar studies have performed: Previous studies have shown that understanding the role of kinases in neuronal development can lead to significant advancements in treating related disorders, indicating a promising avenue for this research.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Guo, Fuzheng — University of California at Davis
- Study coordinator: Guo, Fuzheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.