Investigating how specific proteins affect myelin formation in the brain
Official title: A synaptogenic adhesion code for myelin specificity
Funded at University of Colorado Denver · NIH-11112207 · Data updated 2026-11-12
This study is looking at how certain proteins might affect the protective covering around nerve fibers in the brain, which is important for people with autism, to see if changes in these proteins could help explain some of the brain differences seen in autism.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $429,000 |
| NIH project number | 1R21MH140123-01 |
| Project ID | NIH-11112207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or those exhibiting autism-like symptoms.
✕Less likely to help
Patients without autism spectrum disorder or related neuropsychiatric conditions may not benefit from this research.
What this research studies
This research explores the role of certain proteins in the formation and maintenance of myelin, which is crucial for proper brain function. By examining genetic variants associated with autism spectrum disorder (ASD), the study aims to understand how these variants may disrupt the interaction between myelin and neuronal axons. The researchers will focus on three specific synaptic adhesion molecules to determine their influence on myelin development. This could provide insights into the underlying mechanisms of white matter abnormalities in neuropsychiatric disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving myelin health in individuals with autism spectrum disorder.
How similar studies have gone: While the specific approach of investigating synaptic adhesion molecules in relation to myelin is novel, previous research has shown that understanding genetic variants can lead to breakthroughs in treating neuropsychiatric disorders.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Appel, Bruce H — University of Colorado Denver
- Study coordinator: Appel, Bruce H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.