Investigating how specific proteins affect muscle health in diabetes and aging
Roles of FoxO interactions in diabetic and age-related muscle disease
This study is looking at how specific proteins affect muscle strength and energy in veterans with diabetes and aging, hoping to find ways to help improve muscle health and reduce weakness and fatigue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10918617 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain proteins, known as FoxO transcription factors, influence muscle function in individuals with diabetes and those who are aging. It examines the mechanisms behind muscle weakness and fatigue, particularly in veterans who experience these issues more frequently. By studying mouse models, the research aims to uncover how FoxO proteins interact with other molecules to regulate mitochondrial function in muscle cells, which is crucial for maintaining muscle strength and recovery. The ultimate goal is to identify potential therapeutic targets that could improve muscle health in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans with type 1 or type 2 diabetes who experience muscle weakness and fatigue, as well as older adults facing similar challenges.
Not a fit: Patients without diabetes or significant muscle weakness, or those who are not veterans, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle strength and reduce fatigue in patients with diabetes and age-related muscle diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of FoxO proteins in muscle function, indicating that this approach has potential for success.
Where this research is happening
Iowa City, United States
- Iowa City VA Medical Center — Iowa City, United States (Active)
Researchers
- Principal investigator: O'neill, Brian Timothy — Iowa City VA Medical Center
- Study coordinator: O'neill, Brian Timothy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.