Investigating how specific proteins affect liver health and diabetes.
Novel Roles of Cullin-RING E3 Ligases in Liver Pathophysiology
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-11023068
This study is looking at how certain proteins in the liver might help us understand and treat liver diseases like non-alcoholic fatty liver disease, especially for people dealing with obesity and type-2 diabetes, by finding new ways to improve insulin sensitivity and lower liver fat.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11023068 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Cullin-RING E3 ligases (CRLs) in liver diseases, particularly non-alcoholic fatty liver disease (NAFLD) and its association with obesity and type-2 diabetes. The researchers aim to explore how these ligases regulate lipid and glucose metabolism in the liver, which could lead to new therapeutic targets for treating these conditions. By studying the mechanisms of CRLs, the project seeks to identify potential drug targets that could improve insulin sensitivity and reduce liver fat accumulation. This research is particularly relevant for patients suffering from metabolic disorders linked to liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease, obesity, or type-2 diabetes.
Not a fit: Patients without liver disease or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve liver health and manage diabetes more effectively.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for metabolic diseases, indicating potential for success in this approach.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, TIANGANG — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: LI, TIANGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, anti-cancer research, anti-cancer therapy