Investigating how specific proteins affect heart disease development
Role of ROCK isoform-mediated actin cytoskeleton modification in the pathogenesis of heart disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10762336
This study is looking at how two specific proteins, ROCK1 and ROCK2, affect heart cells and their function, which could help us find new ways to treat heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10762336 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Rho kinase (ROCK) proteins in heart disease, particularly how they influence the structure and function of heart cells. By studying the two types of ROCK proteins, ROCK1 and ROCK2, the research aims to uncover their distinct and shared roles in regulating the actin cytoskeleton, which is crucial for heart function. The researchers will use advanced techniques to manipulate these proteins in heart cells to see how changes affect heart health and disease progression. This could lead to new therapeutic strategies for treating heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk for or currently experiencing cardiovascular diseases.
Not a fit: Patients with non-cardiovascular diseases or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of heart disease.
How similar studies have performed: Previous research has shown that targeting ROCK proteins can be beneficial in other cardiovascular studies, suggesting a promising avenue for this investigation.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEI, LEI — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WEI, LEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cardiovascular disorder, Cardiovascular Diseases