Investigating how specific proteins affect cortisol secretion in adrenal disorders
Official title: Biased AKAP signaling mechanisms
Funded at University of Washington · NIH-11177849 · Data updated 2026-11-12
This study is looking at how certain proteins affect cortisol levels in people with adrenal Cushing’s syndrome, which causes symptoms like weight gain and high blood pressure, to help improve understanding and treatment for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $575,394 |
| NIH project number | 5R01DK141129-02 |
| Project ID | NIH-11177849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with adrenal Cushing’s syndrome, particularly those with specific PKAc mutations.
✕Less likely to help
Patients without adrenal disorders or those not exhibiting the specific mutations related to PKAc may not benefit from this research.
What this research studies
This research focuses on understanding the role of A-Kinase Anchoring Proteins (AKAPs) in the regulation of cortisol secretion, particularly in patients with adrenal Cushing’s syndrome. By studying specific mutations in protein kinase A (PKAc) that lead to excessive cortisol production, the research aims to uncover the mechanisms behind this endocrine disorder. The approach involves examining how these mutations affect protein interactions and cellular signaling within adrenal cells. Patients with adrenal Cushing’s syndrome, which is characterized by symptoms such as weight gain and hypertension, may find this research relevant as it seeks to improve understanding and treatment options for their condition.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for patients suffering from adrenal Cushing’s syndrome.
How similar studies have gone: Previous research has shown promising results in understanding the role of AKAPs in various endocrine disorders, suggesting that this approach may yield significant insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Scott, John D — University of Washington
- Study coordinator: Scott, John D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.