Investigating how specific proteins affect cocaine-seeking behaviors
Official title: Domain- and protein-selective BET mechanisms in cocaine-seeking behaviors
Funded at University of Connecticut Storrs · NIH-11086113 · Data updated 2026-11-12
This study is looking at certain proteins in the brain that might affect cravings and behaviors linked to cocaine addiction, with the hope of finding better and safer treatments for people struggling with substance use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $541,319 |
| NIH project number | 5R01DA058700-03 |
| Project ID | NIH-11086113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of cocaine use or cocaine use disorder.
✕Less likely to help
Patients who do not have a history of cocaine use or those with other types of substance use disorders may not benefit from this research.
What this research studies
This research explores the role of specific proteins in the brain that may influence behaviors related to cocaine addiction. By using targeted treatments and advanced analysis techniques, the study aims to understand how these proteins can be selectively inhibited to reduce cravings and behaviors associated with cocaine use. Patients may benefit from insights that could lead to more effective and safer treatments for substance use disorders. The research focuses on the mechanisms of action of these proteins in response to cocaine, providing a detailed look at how they affect behavior and brain function.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for individuals struggling with cocaine addiction.
How similar studies have gone: Previous research has shown promise in targeting specific proteins for addiction treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Sartor, Gregory Charles — University of Connecticut Storrs
- Study coordinator: Sartor, Gregory Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.