Investigating how specific proteins affect brain health and neurological diseases
Official title: ATase1 and ATase2, proteostasis, and neurological diseases
Funded at University of Wisconsin-Madison · NIH-11009044 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells affect brain health and could help us understand and treat conditions like autism and other neurological disorders, using mouse models to find new ways to improve health for people with these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $270,310 |
| NIH project number | 5R01GM148487-03 |
| Project ID | NIH-11009044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with autism spectrum disorder and related neurological conditions.
✕Less likely to help
Patients with neurological disorders not linked to acetylation or the specific proteins studied may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of acetylation in the endoplasmic reticulum and its impact on brain health and neurological disorders. By studying how certain proteins, specifically ATase1 and ATase2, regulate cellular processes, the research aims to uncover mechanisms that contribute to conditions like autism spectrum disorder and other neurological diseases. The approach includes using mouse models that mimic human genetic mutations to observe disease progression and test potential treatments that restore normal cellular function. Patients may benefit from insights gained about the underlying causes of their conditions and potential new therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of acetylation in cellular processes, suggesting potential for success in this area.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Puglielli, Luigi — University of Wisconsin-Madison
- Study coordinator: Puglielli, Luigi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.