Investigating how specific proteins affect blood stem cells and leukemia
Role of HOTTIP/beta-catenin-HOXA9/PRMT1 axis in hematopoietic and leukemic stem cells
This study is looking at how certain proteins and RNA in blood stem cells might help us find new ways to treat acute myeloid leukemia (AML), so patients can have better treatment options in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10873855 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms that regulate self-renewal in hematopoietic stem cells and leukemia stem cells, particularly looking at the roles of β-catenin and HOXA9. By exploring the interactions between these proteins and the long non-coding RNA HOTTIP, the research aims to uncover potential therapeutic targets for treating acute myeloid leukemia (AML). The approach involves detailed molecular analysis to identify how these factors contribute to the maintenance of stem cell properties and the development of leukemia. Patients may benefit from insights that could lead to new treatment strategies for AML.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with acute myeloid leukemia.
Not a fit: Patients with other types of blood cancers or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in leukemia, suggesting potential for success in this approach.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Huang, Suming — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Huang, Suming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.