Investigating how specific proteins affect B cell development
Official title: Role of a RAG1-DCAF1(VprBP)-Ezh2 axis in B cell development
Funded at Creighton University · NIH-11105910 · Data updated 2026-11-12
This study is looking at how certain proteins help B cells, which are important for your immune system, grow and develop properly, and it hopes to find new ways to help people with immune problems or cancers related to B cell issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | June 5, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $183,750 |
| NIH project number | 5R21AI185362-02 |
| Project ID | NIH-11105910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with B cell deficiencies or related immune disorders.
✕Less likely to help
Patients with conditions unrelated to B cell development or those who do not have immune system disorders may not benefit from this research.
What this research studies
This research explores the role of a protein complex involving RAG1, VprBP, and Ezh2 in the development of B cells, which are crucial for the adaptive immune system. The study focuses on how these proteins interact to regulate the genetic rearrangements necessary for B cell maturation. By understanding these mechanisms, the research aims to uncover how disruptions in this process can lead to immune deficiencies or cancers. Patients may benefit from insights that could lead to new therapies for conditions related to B cell dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for immune deficiencies and certain cancers linked to B cell development.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar protein interactions in immune cell development, suggesting potential for success in this area.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: Swanson, Patrick C. — Creighton University
- Study coordinator: Swanson, Patrick C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.