Investigating how specific proteins affect allergic esophagitis
TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodeling
This study is looking at how certain proteins affect the inflammation and changes in the esophagus for people with Eosinophilic Esophagitis (EoE), with the hope of finding better treatments to help those who struggle with swallowing and food blockages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11093570 on NIH RePORTER |
What this research studies
This research focuses on Eosinophilic Esophagitis (EoE), a condition where the esophagus becomes inflamed due to allergic reactions to certain foods and airborne allergens. The study aims to understand the interactions of specific proteins, TWEAK and LIGHT, in the remodeling of esophageal tissue, which can lead to complications like food impaction and difficulty swallowing. By examining how these proteins influence inflammation and tissue changes, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients suffering from EoE.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Eosinophilic Esophagitis, particularly those experiencing severe symptoms or treatment-resistant disease.
Not a fit: Patients without a diagnosis of Eosinophilic Esophagitis or those whose symptoms are not related to allergic reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively halt or reverse the esophageal remodeling associated with EoE.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory proteins in allergic diseases, suggesting that this approach may yield significant insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Aceves, Seema S — University of California, San Diego
- Study coordinator: Aceves, Seema S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.