Investigating how specific protein interactions affect blood-brain barrier dysfunction in Alzheimer's disease.
Official title: Role of EphA1/A2 domain-domain and -membrane interactions for receptor specificity and Blood Brain Barrier dysfunction
Funded at Case Western Reserve University · NIH-10992001 · Data updated 2026-11-12
This study is looking at how certain proteins called Eph receptors affect the blood-brain barrier in Alzheimer's and other brain diseases, with the hope of finding new ways to help improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $852,309 |
| NIH project number | 1R01AG089561-01 |
| Project ID | NIH-10992001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing early symptoms of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of Eph receptors in the blood-brain barrier (BBB) dysfunction associated with Alzheimer's disease and other neurodegenerative conditions. By examining the molecular mechanisms of Eph receptor interactions, the study aims to identify key protein residues that influence their function. The approach involves detailed analysis of protein structures and their signaling pathways, which could reveal new insights into how these receptors contribute to disease progression. Patients may benefit from findings that could lead to novel therapeutic strategies targeting BBB dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood-brain barrier integrity and potentially slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of Eph receptors in various conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Buck, Matthias — Case Western Reserve University
- Study coordinator: Buck, Matthias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.