Investigating how specific mutations in the p53 gene contribute to breast cancer development.
Role of p53 Missense Mutations on Tumorigenesis in Vivo
This study is looking at how certain changes in the p53 gene might influence the growth of triple negative breast cancer and how the body’s immune system responds, with the hope of finding new ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10755645 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of missense mutations in the p53 tumor suppressor gene, particularly in triple negative breast cancer (TNBC). Using a genetically engineered mouse model, the study aims to explore how these mutations drive tumor growth and affect the immune response. The researchers will analyze tumor behavior and response to treatments, including the use of CRISPR-Cas9 technology to target and potentially eliminate the mutant p53. This approach could provide insights into the biology of TNBC and lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple negative breast cancer, particularly those with p53 mutations.
Not a fit: Patients with other types of breast cancer or those without p53 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with triple negative breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting p53 mutations in cancer, indicating potential for success in this novel approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Lozano, Guillermina — University of Tx Md Anderson Can Ctr
- Study coordinator: Lozano, Guillermina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.