Investigating how specific mRNA changes contribute to Alzheimer's disease
Official title: Cell Type-Specific Alternative polyadenylation of mRNA in Alzheimer's disease
Funded at Texas Tech University Health Scis Center · NIH-10987805 · Data updated 2026-11-12
This study is looking at how a process called alternative polyadenylation affects gene activity in Alzheimer's disease, hoping to find new ways to help treat or prevent the condition by understanding how it influences a protein linked to the disease.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $310,000 |
| NIH project number | 1R03AG087283-01A1 |
| Project ID | NIH-10987805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of alternative polyadenylation (APA) of mRNA in Alzheimer's disease (AD). By examining how APA affects gene expression in specific cell types, the study aims to uncover the molecular mechanisms that contribute to the progression of AD. The researchers will analyze changes in mRNA that may influence the production and clearance of amyloid-β, a key protein involved in AD pathology. This approach could lead to new insights into potential therapeutic targets for treating or preventing Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Alzheimer's disease by targeting specific molecular pathways.
How similar studies have gone: Previous research has shown promising results in understanding gene expression changes in Alzheimer's, but the specific focus on alternative polyadenylation is a novel approach.
Where this research is happening
-
Texas Tech University Health Scis Center
Lubbock, United States Active
Researchers
- Principal investigator: Grozdanov, Petar — Texas Tech University Health Scis Center
- Study coordinator: Grozdanov, Petar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.