Investigating how specific molecules affect gut health in older adults
Roles of circHIPK3 and HuR in aging gut barrier function
This study is looking at how getting older affects the gut's ability to stay healthy and protect against infections, especially after surgery or injury, and it aims to find ways to help improve gut health in older adults by exploring certain proteins and molecules.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10978312 on NIH RePORTER |
What this research studies
This research focuses on understanding how aging impacts the gut barrier function, which is crucial for preventing infections and other complications in older adults. The study will explore the roles of specific RNA-binding proteins and circular RNAs in maintaining gut health, particularly after trauma or surgery. By examining how these molecules influence gene expression and gut cell behavior, the research aims to identify potential therapeutic targets to improve gut integrity in elderly patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be at risk for gut-related complications due to aging.
Not a fit: Patients under the age of 65 or those without gut health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance gut health and reduce the risk of infections in older adults.
How similar studies have performed: Previous research has shown promising results in understanding gut health mechanisms in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Xiao, Lan — University of Maryland Baltimore
- Study coordinator: Xiao, Lan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.