Investigating how specific microRNAs affect retinal health in age-related macular degeneration.
microRNA-204 and microRNA-211 regulation of RPE phagocytosis
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11000296
This study is looking at tiny molecules called microRNAs that help keep the cells in your eyes healthy, which is important for good vision, and it aims to find out how they might play a role in age-related macular degeneration (AMD) to help develop new treatments.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11000296 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of microRNAs, specifically microRNA-204 and microRNA-211, in the health of retinal pigment epithelium (RPE) cells, which are crucial for maintaining vision. The study aims to explore how these microRNAs regulate the RPE's ability to perform essential functions, such as nutrient delivery and the removal of waste from photoreceptors. By examining the expression and regulation of these microRNAs, researchers hope to uncover new insights into the mechanisms behind age-related macular degeneration (AMD) and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing symptoms of age-related macular degeneration.
Not a fit: Patients with other forms of retinal diseases unrelated to age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve or preserve vision in patients with age-related macular degeneration.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in retinal health, indicating that this approach has potential for success.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DU, SAMUEL WANG — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: DU, SAMUEL WANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age related macular disease