Investigating how specific liver cells contribute to liver disease progression
Official title: Pathogenic Role of Foxl1+ Hepatic Progenitor Cells in Fibrotic Liver Disease
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11036242 · Data updated 2026-11-12
This study is looking at special liver cells called Foxl1+ hepatic progenitor cells to see how they affect chronic liver diseases like fibrosis and cirrhosis, which could help find new ways to treat these conditions.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $370,131 |
| NIH project number | 5R37CA225807-07 |
| Project ID | NIH-11036242 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic liver disease, particularly those showing signs of fibrosis or cirrhosis.
✕Less likely to help
Patients with acute liver conditions or those without chronic liver disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of Foxl1+ hepatic progenitor cells (HPCs) in the progression of chronic liver diseases, including fibrosis and cirrhosis. By utilizing a specialized mouse model, the study aims to trace and analyze these cells to determine their impact on liver disease and cancer development. The researchers will explore how HPCs interact with other cells, particularly endothelial cells, and how they may influence processes like angiogenesis and fibrosis. This could lead to identifying new therapeutic targets for treating severe liver conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of chronic liver diseases and associated cancers.
How similar studies have gone: Previous studies have shown promising results in understanding the role of hepatic progenitor cells in liver disease, suggesting that this approach may yield valuable insights.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Shin, Soona — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Shin, Soona
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.