Investigating how specific liver cells contribute to liver disease progression
Pathogenic Role of Foxl1+ Hepatic Progenitor Cells in Fibrotic Liver Disease
['FUNDING_R37'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11036242
This study is looking at special liver cells called Foxl1+ hepatic progenitor cells to see how they affect chronic liver diseases like fibrosis and cirrhosis, which could help find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11036242 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Foxl1+ hepatic progenitor cells (HPCs) in the progression of chronic liver diseases, including fibrosis and cirrhosis. By utilizing a specialized mouse model, the study aims to trace and analyze these cells to determine their impact on liver disease and cancer development. The researchers will explore how HPCs interact with other cells, particularly endothelial cells, and how they may influence processes like angiogenesis and fibrosis. This could lead to identifying new therapeutic targets for treating severe liver conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic liver disease, particularly those showing signs of fibrosis or cirrhosis.
Not a fit: Patients with acute liver conditions or those without chronic liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of chronic liver diseases and associated cancers.
How similar studies have performed: Previous studies have shown promising results in understanding the role of hepatic progenitor cells in liver disease, suggesting that this approach may yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIN, SOONA — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: SHIN, SOONA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers