Investigating how specific immune responses help clear Chlamydia trachomatis infections
Official title: The role of Chlamydia trachomatis specific HLA-E restricted CD8 T cell responses in clearance of infection
Funded at University of Alabama at Birmingham · NIH-10910100 · Data updated 2026-11-12
This study is looking at how our immune system fights off Chlamydia, a common sexually transmitted infection, by focusing on a special type of immune cell called CD8 T cells, and it aims to find ways to help people, especially African Americans and women, clear the infection and avoid getting it again.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | August 18, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $185,625 |
| NIH project number | 5R21AI175809-02 |
| Project ID | NIH-10910100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American individuals and women who are at risk or have been diagnosed with Chlamydia trachomatis infections.
✕Less likely to help
Patients who do not have Chlamydia trachomatis infections or are not part of the targeted demographic may not benefit from this research.
What this research studies
This research focuses on understanding the immune responses to Chlamydia trachomatis (CT), a common bacterial sexually transmitted infection. It particularly examines the role of CD8 T cells, which are a type of immune cell that can recognize and respond to infected cells. The study aims to identify how these immune responses can help clear the infection and prevent reinfection, especially in populations that are disproportionately affected, such as African Americans and women. By analyzing both human and animal models, the research seeks to uncover new insights into the immune mechanisms involved in CT infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating Chlamydia trachomatis infections, particularly in vulnerable populations.
How similar studies have gone: Previous research has shown promising results regarding the role of immune responses in clearing Chlamydia trachomatis infections, indicating that this approach has potential for success.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Bansal, Anju — University of Alabama at Birmingham
- Study coordinator: Bansal, Anju
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.