Investigating how specific immune cells contribute to asthma caused by allergens.
Official title: The Differentiation and Function of heterogeneous populations of Allergen-specific Lung-resident Th2 CD4+ memory cells
Funded at University of Washington · NIH-11012321 · Data updated 2026-11-12
This study is looking at how certain immune cells in your lungs might be involved in causing and keeping asthma symptoms going when you're exposed to allergens, with the hope of finding better ways to manage and treat asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $841,731 |
| NIH project number | 5R01AI177874-02 |
| Project ID | NIH-11012321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with allergic asthma, particularly those sensitive to house dust mites.
✕Less likely to help
Patients with non-allergic asthma or those whose asthma is not triggered by specific allergens may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific immune cells, known as Th2 CD4+ memory cells, in the development and persistence of asthma triggered by allergens. By using advanced techniques to track these cells in the lungs, the study aims to uncover how they contribute to allergic inflammation and asthma symptoms. The researchers will utilize a specialized method to isolate and analyze these cells, which could lead to new insights into asthma management and treatment.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve asthma control and reduce allergic reactions in patients.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Pepper, Marion — University of Washington
- Study coordinator: Pepper, Marion
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.