Investigating how specific immune cells contribute to AIDS-related lymphoma.
The Role of Follicular CD8+ T Cells in Pathogenesis of AIDS-NHL.
This study is looking at how a special type of immune cell might play a role in the development of non-Hodgkin lymphoma in people with AIDS, and it aims to find out how these cells interact with other immune cells to help improve future treatments for those living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10674532 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific type of immune cell, known as follicular CD8+ T cells, in the development of non-Hodgkin lymphoma associated with AIDS. The study examines how these immune cells interact with B cells and how their dysfunction may lead to cancer in individuals with HIV. By analyzing immune responses and cellular interactions in patients, the research aims to uncover mechanisms that could inform new treatment strategies. Patients may be involved in providing samples or data to help elucidate these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with HIV who are at risk for developing non-Hodgkin lymphoma.
Not a fit: Patients who do not have HIV or those who have already been diagnosed with non-Hodgkin lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new therapies for patients with AIDS-related lymphoma.
How similar studies have performed: Previous research has shown promise in understanding immune cell interactions in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Epeldegui, Marta — University of California Los Angeles
- Study coordinator: Epeldegui, Marta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.