Investigating how specific immune cells and gut bacteria affect inflammation in people with HIV
Gamma Delta T cell and microbial modulation to target chronic SIV-associated inflammation
This study is looking at how certain immune cells can help keep your gut healthy and reduce inflammation if you have HIV and are on treatment, and it may offer new ways to improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11103327 on NIH RePORTER |
What this research studies
This research focuses on understanding the immune mechanisms that lead to gut dysfunction and inflammation in individuals living with HIV who are on antiretroviral therapy. It aims to explore the role of a specific type of immune cell, known as gamma delta T cells, in maintaining gut health and preventing inflammation. By stimulating and expanding these cells in a controlled setting, the study will assess their impact on gut barrier integrity and microbial balance. Patients may be involved in interventions that could help improve their overall health outcomes related to HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently receiving antiretroviral therapy and experiencing related health issues.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that reduce inflammation and improve gut health in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in gut health, indicating that this approach may lead to significant advancements.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Rout, Namita — Tulane University of Louisiana
- Study coordinator: Rout, Namita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.