Investigating how specific immune cells affect interactions between T cells and B cells in arthritis.
T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis
This study is looking at how certain immune cells work together in the joints of kids with juvenile idiopathic arthritis to help produce antibodies, with the hope of finding new ways to manage excessive antibody production that can worsen the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001150 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between T peripheral helper cells and B cells, which are crucial for antibody production in arthritis. It aims to explore how these interactions occur in inflamed tissues rather than just in lymphoid organs. By analyzing joint fluid from patients with juvenile idiopathic arthritis, the study seeks to identify a new subset of T cells that may help regulate these interactions. The goal is to uncover the mechanisms that lead to excessive antibody production in chronic inflammatory arthritis.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with chronic inflammatory arthritis, particularly those with juvenile idiopathic arthritis and positive anti-nuclear antibodies.
Not a fit: Patients with non-inflammatory arthritis or those without autoimmune components may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing arthritis by targeting specific immune cell interactions.
How similar studies have performed: Previous research has shown promising results in understanding immune cell interactions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Henderson, Lauren a — Boston Children's Hospital
- Study coordinator: Henderson, Lauren a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.