Investigating how specific heart cells contribute to heart failure and healing in adults
The Roles of Neural Crest Derived Cardiomyocytes in Adult-Onset Heart Failure and Regeneration
This study is looking at special heart cells in zebrafish to see how they help the heart work and heal, which could lead to better treatments for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10558575 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Neural Crest derived Cardiomyocytes (NC-Cms) in adult heart failure and regeneration. By creating novel zebrafish models, the researchers can observe how the absence of these specific heart cells affects heart function and structure over time. The study employs advanced genetic techniques to manipulate these cells and assess their impact on heart health, particularly under stress conditions. This approach aims to uncover potential pathways for improving heart regeneration and treatment strategies for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure or those at risk of developing heart-related conditions.
Not a fit: Patients with congenital heart defects or those who have not reached adulthood may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart regeneration and improve outcomes for patients with heart failure.
How similar studies have performed: Other research has shown promise in using animal models to study heart regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Tristani-Firouzi, Martin — University of Utah
- Study coordinator: Tristani-Firouzi, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.